VIP (Vasoactive Intestinal Peptide)
Synthetic peptide studied in animal and cell models for neuroprotection and neurotrophic support and anti-inflammatory immune modulation
Last updated: March 1, 2026
- Compound
- VIP (Vasoactive Intestinal Peptide)
- Class
- Cognitive peptide
- Summary
- Synthetic peptide studied in animal and cell models for neuroprotection and neurotrophic support, anti-inflammatory immune modulation, circadian rhythm regulation.
- Mechanism
- Vascular Smooth Muscle Relaxation
- Research Status
- Phase II
- Routes Studied
- Subcutaneous injection
- Evidence Level
- Preclinical-promising · Clinically unproven
What Should You Know About VIP (Vasoactive Intestinal Peptide)?
- What is VIP (Vasoactive Intestinal Peptide)?
- VIP (Vasoactive Intestinal Peptide) is a synthetic peptide studied in animal and cell models for neuroprotection and neurotrophic support and anti-inflammatory immune modulation.
- Is VIP (Vasoactive Intestinal Peptide) clinically proven?
- No. Human evidence remains limited and does not establish VIP (Vasoactive Intestinal Peptide) as clinically proven.
- What has VIP (Vasoactive Intestinal Peptide) been studied for?
- VIP (Vasoactive Intestinal Peptide) has been studied in preclinical models of neuroprotection and neurotrophic support, anti-inflammatory immune modulation, circadian rhythm regulation. These findings have not been confirmed in large-scale human trials.
- Is VIP (Vasoactive Intestinal Peptide) approved?
- No. VIP (Vasoactive Intestinal Peptide) is not an approved drug and remains a research compound.
What Is VIP (Vasoactive Intestinal Peptide)?
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid linear neuropeptide belonging to the glucagon/secretin superfamily of regulatory peptides. First isolated from porcine small intestine by Said and Mutt in 1970, VIP was initially characterized for its potent vasodilatory properties. Subsequent decades of research revealed that VIP functions as a widely distributed neuropeptide and neuromodulator, expressed throughout the central and peripheral nervous systems, immune system, gastrointestinal tract, pulmonary epithelium, and cardiovascular...
Evidence Summary
VIP (Vasoactive Intestinal Peptide) is a research compound with promising biological signals but limited human validation. Most claims exceed current clinical evidence.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Neuroprotection and Neurotrophic Support | Limited |
| Anti-Inflammatory Immune Modulation | Limited |
| Circadian Rhythm Regulation | Limited |
| Pulmonary and Vascular Function | Limited |
| Human clinical evidence | Limited |
| Safety data | Insufficient |
Editorial Position
VIP (Vasoactive Intestinal Peptide) is best understood as a compound with emerging clinical evidence that has not yet reached definitive conclusions. Many online claims exceed the strength of available human evidence, and safety data remains incomplete. Any consideration of this compound should involve careful evaluation of individual context and medical guidance.
Regulatory Status Snapshot
- Not approved as a therapeutic drug by major regulators
- Safety profile not established in large human populations
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for VIP (Vasoactive Intestinal Peptide) is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has VIP (Vasoactive Intestinal Peptide) Been Studied For?
Research areas where VIP (Vasoactive Intestinal Peptide) has been investigated in published studies
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Neuroprotection and Neurotrophic Support VIP (Vasoactive Intestinal Peptide) has been studied in animal models of neuroprotection and neurotrophic support. These findings have not been confirmed in controlled human trials.
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Anti-Inflammatory Immune Modulation VIP (Vasoactive Intestinal Peptide) has been studied in animal models of anti-inflammatory immune modulation. These findings have not been confirmed in controlled human trials.
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Circadian Rhythm Regulation VIP (Vasoactive Intestinal Peptide) has been studied in animal models of circadian rhythm regulation. These findings have not been confirmed in controlled human trials.
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Pulmonary and Vascular Function VIP (Vasoactive Intestinal Peptide) has been studied in animal models of pulmonary and vascular function. These findings have not been confirmed in controlled human trials.
How Does VIP (Vasoactive Intestinal Peptide) Work?
These mechanisms have been observed in preclinical models. They are plausible but have not been linked to proven clinical outcomes in humans.
- 01 Receptor interaction
- 02 Intracellular signaling
- 03 Neuroprotective Gene Transcription
- 04 NF-kappaB Inhibition & Immune Modulation
Not sure if VIP (Vasoactive Intestinal Peptide) is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about VIP (Vasoactive Intestinal Peptide).
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
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How Is VIP (Vasoactive Intestinal Peptide) Administered?
VIP (Vasoactive Intestinal Peptide) is available via Subcutaneous injection. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of VIP (Vasoactive Intestinal Peptide)?
What Conditions Has VIP (Vasoactive Intestinal Peptide) Been Linked To?
Have Questions About VIP (Vasoactive Intestinal Peptide)?
VIP's plasma half-life of approximately 1-2 minutes results from rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-IV) and neutral endopeptidase, both of which are abundant in plasma and on endothelial cell surfaces.
Published studies on VIP (Vasoactive Intestinal Peptide) can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
VIP (Vasoactive Intestinal Peptide) is available as a research compound in Thailand. Consult a qualified specialist to discuss whether it is appropriate for your needs.
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Last reviewed: March 1, 2026