DSIP
Synthetic peptide studied in animal and cell models for delta sleep and cortisol regulation
Last updated: March 1, 2026
- Compound
- DSIP
- Class
- Sleep & Circadian peptide
- Summary
- Synthetic peptide studied in animal and cell models for delta sleep, cortisol regulation, non-sedative sleep improvement.
- Mechanism
- Sustained Sleep Architecture Improvement
- Research Status
- Phase I
- Routes Studied
- Subcutaneous injection
- Evidence Level
- Early-stage research · Clinically unproven
What Should You Know About DSIP?
- What is DSIP?
- DSIP is a synthetic peptide studied in animal and cell models for delta sleep and cortisol regulation.
- Is DSIP clinically proven?
- No. Human evidence remains limited and does not establish DSIP as clinically proven.
- What has DSIP been studied for?
- DSIP has been studied in preclinical models of delta sleep, cortisol regulation, non-sedative sleep improvement. These findings have not been confirmed in large-scale human trials.
- Is DSIP approved?
- No. DSIP is not an approved drug and remains a research compound.
What Is DSIP?
Delta Sleep Inducing Peptide (DSIP) is a naturally occurring neuropeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. First isolated in 1977 from the cerebral venous blood of rabbits in induced sleep states by Swiss researchers Schoenenberger and Monnier, DSIP was identified as a factor capable of promoting delta (slow-wave) sleep, the deepest and most restorative phase of the sleep cycle. Its discovery opened a new frontier in understanding the peptidergic regulation...
Evidence Summary
DSIP has early-stage clinical data only. Safety data is emerging but efficacy evidence remains limited. Most claims exceed current clinical evidence.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Delta Sleep | Limited |
| Cortisol Regulation | Limited |
| Non-Sedative Sleep Improvement | Limited |
| Stress Resilience | Limited |
| Human clinical evidence | Limited |
| Safety data | Insufficient |
Editorial Position
DSIP is best understood as a preclinical research compound with promising biological signals but limited human validation. Many online claims exceed the strength of available human evidence, and safety data remains incomplete. Any consideration of this compound should involve careful evaluation of individual context and medical guidance.
Regulatory Status Snapshot
- Not approved as a therapeutic drug by major regulators
- Safety profile not established in large human populations
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for DSIP is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has DSIP Been Studied For?
Research areas where DSIP has been investigated in published studies
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Delta Sleep DSIP has been studied in animal models of delta sleep. These findings have not been confirmed in controlled human trials.
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Cortisol Regulation DSIP has been studied in animal models of cortisol regulation. These findings have not been confirmed in controlled human trials.
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Non-Sedative Sleep Improvement DSIP has been studied in animal models of non-sedative sleep improvement. These findings have not been confirmed in controlled human trials.
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Stress Resilience DSIP has been studied in animal models of stress resilience. These findings have not been confirmed in controlled human trials.
How Does DSIP Work?
These mechanisms have been observed in preclinical models. They are plausible but have not been linked to proven clinical outcomes in humans.
- 01 Sleep Center Modulation
- 02 Cortisol Rhythm Normalization
- 03 Melatonin Timing Optimization
- 04 Stress-Response Dampening
Not sure if DSIP is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about DSIP.
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
Rate DSIP
How Is DSIP Administered?
DSIP is available via Subcutaneous injection, auto-injector pen. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of DSIP?
What Conditions Has DSIP Been Linked To?
Have Questions About DSIP?
Published studies on DSIP can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
DSIP is available as a research compound in Thailand. Consult a qualified specialist to discuss whether it is appropriate for your needs.
A qualified specialist experienced with peptide therapies can help you understand the current evidence and determine suitability.
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Book a Consultation Free initial consultation. No obligation.Reviewed by the Peptide Science Thailand Editorial Team.
Last reviewed: March 1, 2026