Selank
Synthetic peptide studied in clinical and preclinical models for anxiolysis without sedation and preserved cognitive function
Last updated: March 1, 2026
- Compound
- Selank
- Class
- Cognitive peptide
- Summary
- Synthetic peptide studied in clinical and preclinical models for anxiolysis without sedation, preserved cognitive function, immune system modulation.
- Mechanism
- Hippocampal Gene Expression
- Research Status
- Approved
- Routes Studied
- Intranasal administration
- Evidence Level
- Clinically validated · Approved therapeutic
What Should You Know About Selank?
- What is Selank?
- Selank is a synthetic peptide studied in clinical and preclinical models for anxiolysis without sedation and preserved cognitive function.
- Is Selank clinically proven?
- Selank is an approved therapeutic with established clinical evidence.
- What has Selank been studied for?
- Selank has been studied in clinical and preclinical settings of anxiolysis without sedation, preserved cognitive function, immune system modulation and has received regulatory approval in at least one jurisdiction.
- Is Selank approved?
- Selank is an approved therapeutic in at least one jurisdiction. Regulatory status varies by country. Consult a local specialist for guidance.
What Is Selank?
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analogue of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). By extending tuftsin's tetrapeptide sequence with a Pro-Gly-Pro tripeptide tail, a structural motif that enhances metabolic stability, researchers created a compound with significantly improved bioavailability and an expanded pharmacological profile that encompasses both anxiolytic and nootropic properties.
Evidence Summary
Selank is an approved therapeutic with established clinical evidence and regulatory approval in at least one jurisdiction.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Anxiolysis Without Sedation | Limited |
| Preserved Cognitive Function | Limited |
| Immune System Modulation | Limited |
| No Dependence or Tolerance | Limited |
| Human clinical evidence | Established |
| Safety data | Established |
Editorial Position
Selank is an approved therapeutic with established clinical evidence. As with any pharmaceutical compound, individual suitability should be discussed with a specialist.
Regulatory Status Snapshot
- Approved as a therapeutic drug in at least one jurisdiction
- Safety and efficacy established through regulatory review processes
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for Selank is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has Selank Been Studied For?
Research areas where Selank has been investigated in published studies
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Anxiolysis Without Sedation Selank has been studied in clinical and preclinical studies of anxiolysis without sedation.
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Preserved Cognitive Function Selank has been studied in clinical and preclinical studies of preserved cognitive function.
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Immune System Modulation Selank has been studied in clinical and preclinical studies of immune system modulation.
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No Dependence or Tolerance Selank has been studied in clinical and preclinical studies of no dependence or tolerance.
How Does Selank Work?
These mechanisms have been established through clinical and preclinical research.
- 01 GABA-A Receptor Subunit Modulation
- 02 Serotonergic Metabolism Modulation
- 03 Dopaminergic Fine-Tuning
- 04 Immunomodulatory Signaling
Not sure if Selank is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about Selank.
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
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How Is Selank Administered?
Selank is available via Intranasal administration. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of Selank?
What Conditions Has Selank Been Linked To?
Have Questions About Selank?
Selank's origin as a tuftsin analogue gives it immunomodulatory properties that traditional anxiolytics lack. Research shows it modulates interleukin and interferon gene expression, potentially rebalancing immune function disrupted by chronic stress.
Selank and Semax are complementary nootropic peptides developed at the same Russian research institute. Selank primarily provides anxiolytic (calming) effects through GABAergic modulation while preserving cognition. Semax primarily provides stimulating nootropic effects through BDNF upregulation and dopaminergic enhancement.
Published studies on Selank can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
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Book a Consultation Free initial consultation. No obligation.Reviewed by the Peptide Science Thailand Editorial Team.
Last reviewed: March 1, 2026