Noopept
Synthetic peptide studied in clinical and preclinical models for memory and learning and neuroprotective activity
Last updated: March 1, 2026
- Compound
- Noopept
- Class
- Cognitive peptide
- Summary
- Synthetic peptide studied in clinical and preclinical models for memory and learning, neuroprotective activity, anti-neuroinflammatory effects.
- Mechanism
- Neuroprotective Cascade
- Research Status
- Phase III
- Routes Studied
- Oral or sublingual administration; injectable formulations are also used in research settings
- Evidence Level
- Late-stage clinical · Clinically tested
What Should You Know About Noopept?
- What is Noopept?
- Noopept is a synthetic peptide studied in clinical and preclinical models for memory and learning and neuroprotective activity.
- Is Noopept clinically proven?
- No. Human evidence remains limited and does not establish Noopept as clinically proven.
- What has Noopept been studied for?
- Noopept has been studied in clinical and preclinical settings of memory and learning, neuroprotective activity, anti-neuroinflammatory effects. Late-stage clinical trials have been conducted, though final regulatory outcomes may vary by jurisdiction.
- Is Noopept approved?
- Noopept is in late-stage clinical development but has not yet received full regulatory approval in all jurisdictions. Consult a local specialist for current status.
What Is Noopept?
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, also known as GVS-111 or Omberacetam) is a synthetic dipeptide-derived nootropic compound originally developed at the Zakusov Research Institute of Pharmacology in Moscow during the 1990s. Structurally, Noopept is a modified cycloprolylglycine dipeptide that shares a pharmacological relationship with the racetam family of compounds, although it is not technically a racetam due to its distinct chemical structure. Its molecular formula is C17H22N2O4 with a molecular weight...
Evidence Summary
Noopept has reached late-stage clinical trials (Phase III). Substantial human data exists, though final regulatory outcomes may still be pending.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Memory and Learning | Limited |
| Neuroprotective Activity | Limited |
| Anti-Neuroinflammatory Effects | Limited |
| Anxiolytic Properties | Limited |
| Human clinical evidence | Substantial |
| Safety data | Insufficient |
Editorial Position
Noopept is best understood as a compound with emerging clinical evidence that has not yet reached definitive conclusions. Many online claims exceed the strength of available human evidence, and safety data remains incomplete. Any consideration of this compound should involve careful evaluation of individual context and medical guidance.
Regulatory Status Snapshot
- Late-stage clinical trials conducted; not yet approved in all jurisdictions
- Safety data from clinical trials available but regulatory review ongoing
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for Noopept is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has Noopept Been Studied For?
Research areas where Noopept has been investigated in published studies
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Memory and Learning Noopept has been studied in clinical and preclinical studies of memory and learning.
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Neuroprotective Activity Noopept has been studied in clinical and preclinical studies of neuroprotective activity.
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Anti-Neuroinflammatory Effects Noopept has been studied in clinical and preclinical studies of anti-neuroinflammatory effects.
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Anxiolytic Properties Noopept has been studied in clinical and preclinical studies of anxiolytic properties.
How Does Noopept Work?
These mechanisms have been studied in clinical and preclinical settings. Clinical trials are ongoing or completed.
- 01 Blood-Brain Barrier Penetration
- 02 BDNF and NGF Upregulation
- 03 AMPA Receptor Modulation
- 04 Cholinergic Enhancement
Not sure if Noopept is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about Noopept.
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
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How Is Noopept Administered?
Noopept is available via Oral or sublingual administration; injectable formulations are also used in research settings. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of Noopept?
What Conditions Has Noopept Been Linked To?
Have Questions About Noopept?
Noopept is a synthetic dipeptide derivative, meaning it is derived from a two-amino-acid peptide backbone (prolylglycine) with additional chemical modifications.
Noopept is rapidly absorbed, reaching peak plasma and brain concentrations within 15-20 minutes of oral administration. Some acute cognitive effects may be observed within this timeframe.
Published studies on Noopept can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
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Last reviewed: March 1, 2026