MK-677 (Ibutamoren)
Synthetic peptide studied in animal and cell models for sustained growth hormone elevation and body composition
Last updated: March 1, 2026
- Compound
- MK-677 (Ibutamoren)
- Class
- Body Composition peptide
- Summary
- Synthetic peptide studied in animal and cell models for sustained growth hormone elevation, body composition, sleep quality.
- Mechanism
- Anabolic and Metabolic Downstream Effects
- Research Status
- Phase II
- Routes Studied
- Oral administration
- Evidence Level
- Preclinical-promising · Clinically unproven
What Should You Know About MK-677 (Ibutamoren)?
- What is MK-677 (Ibutamoren)?
- MK-677 (Ibutamoren) is a synthetic peptide studied in animal and cell models for sustained growth hormone elevation and body composition.
- Is MK-677 (Ibutamoren) clinically proven?
- No. Human evidence remains limited and does not establish MK-677 (Ibutamoren) as clinically proven.
- What has MK-677 (Ibutamoren) been studied for?
- MK-677 (Ibutamoren) has been studied in preclinical models of sustained growth hormone elevation, body composition, sleep quality. These findings have not been confirmed in large-scale human trials.
- Is MK-677 (Ibutamoren) approved?
- No. MK-677 (Ibutamoren) is not an approved drug and remains a research compound.
What Is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren or Ibutamoren Mesylate, is a potent, orally active, non-peptide growth hormone secretagogue developed by Merck Research Laboratories in the mid-1990s. Unlike traditional growth hormone-releasing peptides (GHRPs) that require injection, MK-677 is a small molecule compound with the molecular formula C27H36N4O5S and a molecular weight of 528.66 g/mol. It functions as a selective agonist of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin...
Evidence Summary
MK-677 (Ibutamoren) is a research compound with promising biological signals but limited human validation. Most claims exceed current clinical evidence.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Sustained Growth Hormone Elevation | Limited |
| Body Composition | Limited |
| Sleep Quality | Limited |
| Bone Metabolism Support | Limited |
| Human clinical evidence | Limited |
| Safety data | Insufficient |
Editorial Position
MK-677 (Ibutamoren) is best understood as a compound with emerging clinical evidence that has not yet reached definitive conclusions. Many online claims exceed the strength of available human evidence, and safety data remains incomplete. Any consideration of this compound should involve careful evaluation of individual context and medical guidance.
Regulatory Status Snapshot
- Not approved as a therapeutic drug by major regulators
- Safety profile not established in large human populations
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for MK-677 (Ibutamoren) is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has MK-677 (Ibutamoren) Been Studied For?
Research areas where MK-677 (Ibutamoren) has been investigated in published studies
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Sustained Growth Hormone Elevation MK-677 (Ibutamoren) has been studied in animal models of sustained growth hormone elevation. These findings have not been confirmed in controlled human trials.
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Body Composition MK-677 (Ibutamoren) has been studied in animal models of body composition. These findings have not been confirmed in controlled human trials.
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Sleep Quality MK-677 (Ibutamoren) has been studied in animal models of sleep quality. These findings have not been confirmed in controlled human trials.
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Bone Metabolism Support MK-677 (Ibutamoren) has been studied in animal models of bone metabolism support. These findings have not been confirmed in controlled human trials.
How Does MK-677 (Ibutamoren) Work?
These mechanisms have been observed in preclinical models. They are plausible but have not been linked to proven clinical outcomes in humans.
- 01 GHSR-1a Receptor Binding
- 02 Calcium-Mediated GH Exocytosis
- 03 Downstream biological effect
- 04 Sustained IGF-1 Elevation
Not sure if MK-677 (Ibutamoren) is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about MK-677 (Ibutamoren).
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
Rate MK-677 (Ibutamoren)
How Is MK-677 (Ibutamoren) Administered?
MK-677 (Ibutamoren) is available via Oral administration. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of MK-677 (Ibutamoren)?
What Conditions Has MK-677 (Ibutamoren) Been Linked To?
Have Questions About MK-677 (Ibutamoren)?
Published studies on MK-677 (Ibutamoren) can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
MK-677 (Ibutamoren) is available as a research compound in Thailand. Consult a qualified specialist to discuss whether it is appropriate for your needs.
A qualified specialist experienced with peptide therapies can help you understand the current evidence and determine suitability.
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Book a Consultation Free initial consultation. No obligation.Reviewed by the Peptide Science Thailand Editorial Team.
Last reviewed: March 1, 2026