Humanin
Synthetic peptide studied in animal and cell models for cytoprotection and neuroprotection
Last updated: March 1, 2026
- Compound
- Humanin
- Class
- Longevity peptide
- Summary
- Synthetic peptide studied in animal and cell models for cytoprotection, neuroprotection, metabolic regulation.
- Mechanism
- Metabolic & Insulin Signaling Enhancement
- Research Status
- Preclinical
- Routes Studied
- Subcutaneous or intraperitoneal injection (research context dependent)
- Evidence Level
- Preclinical-promising · Clinically unproven
What Should You Know About Humanin?
- What is Humanin?
- Humanin is a synthetic peptide studied in animal and cell models for potent cytoprotection and neuroprotection.
- Is Humanin clinically proven?
- No. Human evidence remains limited and does not establish Humanin as clinically proven.
- What has Humanin been studied for?
- Humanin has been studied in preclinical models of potent cytoprotection, neuroprotection, metabolic regulation. These findings have not been confirmed in large-scale human trials.
- Is Humanin approved?
- No. Humanin is not an approved drug and remains a research compound.
What Is Humanin?
Humanin is a 24-amino acid peptide encoded by the 16S ribosomal RNA region of the mitochondrial genome, making it one of the first identified mitochondrial-derived peptides (MDPs). Discovered in 2001 by Nishimoto and colleagues through a functional expression screening of a cDNA library from the occipital cortex, Humanin was initially identified for its ability to protect neuronal cells from apoptosis induced by multiple neurotoxic insults. The peptide's sequence (Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala) is...
Evidence Summary
Humanin has extensive preclinical evidence (60+ PubMed citations) but no human clinical trial data. Most claims exceed current evidence.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Cytoprotection | Animal studies |
| Neuroprotection | Animal studies |
| Metabolic Regulation | Animal studies |
| Longevity Association | Animal studies |
| Human clinical evidence | Limited |
| Safety data | Insufficient |
Editorial Position
Humanin is best understood as a preclinical research compound with promising biological signals but limited human validation. Many online claims exceed the strength of available human evidence, and safety data remains incomplete. Any consideration of this compound should involve careful evaluation of individual context and medical guidance.
Regulatory Status Snapshot
- Not approved as a therapeutic drug by major regulators
- Safety profile not established in large human populations
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for Humanin is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has Humanin Been Studied For?
Research areas where Humanin has been investigated in published studies
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Cytoprotection Humanin has been studied in animal models of cytoprotection. These findings have not been confirmed in controlled human trials.
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Neuroprotection Humanin has been studied in animal models of neuroprotection. These findings have not been confirmed in controlled human trials.
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Metabolic Regulation Humanin has been studied in animal models of metabolic regulation. These findings have not been confirmed in controlled human trials.
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Longevity Association Humanin has been studied in animal models of longevity association. These findings have not been confirmed in controlled human trials.
How Does Humanin Work?
These mechanisms have been observed in preclinical models. They are plausible but have not been linked to proven clinical outcomes in humans.
- 01 Trimeric Receptor Complex Binding
- 02 JAK-STAT3 Pathway Activation
- 03 Bax Sequestration & MOMP Prevention
- 04 IGFBP-3 Interaction
Not sure if Humanin is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about Humanin.
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
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How Is Humanin Administered?
Humanin is available via Subcutaneous or intraperitoneal injection (research context dependent). Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of Humanin?
What Conditions Has Humanin Been Linked To?
Have Questions About Humanin?
Published studies on Humanin can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
Humanin is available as a research compound in Thailand. Consult a qualified specialist to discuss whether it is appropriate for your needs.
A qualified specialist experienced with peptide therapies can help you understand the current evidence and determine suitability.
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Book a Consultation Free initial consultation. No obligation.Reviewed by the Peptide Science Thailand Editorial Team.
Last reviewed: March 1, 2026