HCG
Synthetic peptide studied in clinical and preclinical models for gonadal function preservation and spermatogenesis support
Last updated: March 1, 2026
- Compound
- HCG
- Class
- Sexual Wellness peptide
- Summary
- Synthetic peptide studied in clinical and preclinical models for gonadal function preservation, spermatogenesis support, hormonal balance maintenance.
- Mechanism
- Systemic Androgen & Metabolic Effects
- Research Status
- Approved
- Routes Studied
- Subcutaneous injection via auto-injector pen
- Evidence Level
- Clinically validated · Approved therapeutic
What Should You Know About HCG?
- What is HCG?
- HCG is a synthetic peptide studied in clinical and preclinical models for gonadal function preservation and spermatogenesis support.
- Is HCG clinically proven?
- HCG is an approved therapeutic with established clinical evidence.
- What has HCG been studied for?
- HCG has been studied in clinical and preclinical settings of gonadal function preservation, spermatogenesis support, hormonal balance maintenance and has received regulatory approval in at least one jurisdiction.
- Is HCG approved?
- HCG is an approved therapeutic in at least one jurisdiction. Regulatory status varies by country. Consult a local specialist for guidance.
What Is HCG?
Human chorionic gonadotropin (HCG) is a heterodimeric glycoprotein hormone consisting of two non-covalently linked subunits: an alpha subunit of 92 amino acids that is shared with luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH), and a unique beta subunit of 145 amino acids that confers biological specificity. The beta subunit contains extensive glycosylation with both N-linked and O-linked oligosaccharides that are critical for receptor binding, signal transduction, and...
Evidence Summary
HCG is an approved therapeutic with established clinical evidence and regulatory approval in at least one jurisdiction.
Evidence Breakdown
| Domain | Evidence Level |
|---|---|
| Gonadal Function Preservation | Limited |
| Spermatogenesis Support | Limited |
| Hormonal Balance Maintenance | Limited |
| Reproductive Medicine Applications | Limited |
| Human clinical evidence | Established |
| Safety data | Established |
Editorial Position
HCG is an approved therapeutic with established clinical evidence. As with any pharmaceutical compound, individual suitability should be discussed with a specialist.
Regulatory Status Snapshot
- Approved as a therapeutic drug in at least one jurisdiction
- Safety and efficacy established through regulatory review processes
Need help interpreting this evidence for your situation?
Talk to a SpecialistA deep research review for HCG is not yet available. This compound profile is based on published peer-reviewed references listed below.
Browse all research reviewsWhat Has HCG Been Studied For?
Research areas where HCG has been investigated in published studies
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Gonadal Function Preservation HCG has been studied in clinical and preclinical studies of gonadal function preservation.
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Spermatogenesis Support HCG has been studied in clinical and preclinical studies of spermatogenesis support.
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Hormonal Balance Maintenance HCG has been studied in clinical and preclinical studies of hormonal balance maintenance.
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Reproductive Medicine Applications HCG has been studied in clinical and preclinical studies of reproductive medicine applications.
How Does HCG Work?
These mechanisms have been established through clinical and preclinical research.
- 01 LHCGR Receptor Activation
- 02 StAR Protein Activation & Cholesterol Transport
- 03 Steroidogenesis Cascade Initiation
- 04 Intratesticular Hormone Milieu Maintenance
Not sure if HCG is right for you?
A specialist can review the evidence, evaluate your medical context, and help you make an informed decision about HCG.
Community Reports (Anecdotal)
Experiences shared here are self-reported and do not represent clinical evidence.
Rate HCG
How Is HCG Administered?
HCG is available via Subcutaneous injection via auto-injector pen. Appropriate use and protocol should be determined by a qualified specialist.
What Are the Specifications of HCG?
Have Questions About HCG?
Exogenous testosterone suppresses pituitary LH and FSH secretion through negative feedback, which leads to decreased intratesticular testosterone production, reduced spermatogenesis, and testicular atrophy.
Yes. HCG stimulates Leydig cell testosterone production, and a portion of this testosterone is converted to estradiol by the aromatase enzyme. HCG also directly upregulates aromatase activity.
Published studies on HCG can be found on PubMed and other peer-reviewed databases. Our references section below lists key citations.
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Book a Consultation Free initial consultation. No obligation.Reviewed by the Peptide Science Thailand Editorial Team.
Last reviewed: March 1, 2026